Found this on the fix list for Notes / Domino 8.5.3
SPR# KMUR63DF3V – Fix introduces an ini DEBUG_AMGR_ENABLE_RETRY_ON_COMPACT to allow an agent to run on a time interval once database compact is complete. Previously when a database was being compacted and an attempt was made to load a scheduled agent it would fail and the agent would be marked to not run again unless the user restarted the agent manager or the agent cache refreshed. This fix introduces a notes.ini variable to allow the agent in question to be retried on it’s subsequent time interval.
There are also some other new notes.ini entrys in 8.5.3 … you can find them here: http://www.lntoolbox.com/en/notesini-reference/by-release.html?choosenlotusrelease=8.5.3&limit=20