Seems like the well known spammer located in Amsterdam has choosen my blog for comment spam.
Akismet does a great job ( 69,466 spams caught, 336,274 legitimate comments, and an overall accuracy rate of 99.994%.) but I saw a lot of comments over the last 24 hours not filtered by Akismet. So I (re-) activated WP-Ban again and are now able to stop the comment spam (for a while).
The internet would be so much faster and even more valuable if these f**ckers would not exist.